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Table. 2. Multivariate Cox regression to assess the association between the RDW and 30-day mortality
Variables Normal RDW Elevated RDW RDW
HR HR (95% CI) P HR (95% CI) P
Unadjusted 1 2.32 (2.14–2.52) <0.001 1.19 (1.17–1.21) <0.001
Model 1* 1 2.20 (2.02–2.39) <0.001 1.17 (1.16–1.19) <0.001
Model 2 1 2.00 (1.83–2.18) <0.001 1.16 (1.14–1.18) <0.001
Model 3 1 1.83 (1.68–2.00) <0.001 1.13 (1.11–1.15) <0.001
Model 4§ 1 1.84 (1.69–2.01) <0.001 1.13 (1.11–1.15) <0.001
Model 5ІІ 1 1.79 (1.64–1.96) <0.001 1.12 (1.10–1.14) <0.001

*Models 1–5 were derived from multivariate Cox regression models. Model 1 covariates were adjusted for sex, age, and body–mass index (BMI).

Model 2 covariates were adjusted for sex, age, BMI, myocardial infarction, congestive heart failure, cerebrovascular disease, chronic pulmonary disease, diabetes with complications, and renal disease.

Model 3 covariates were adjusted for sex, age, BMI, myocardial infarction, congestive heart failure, cerebrovascular disease, chronic pulmonary disease, diabetes with complications, renal disease, Charlson comorbidity index, sequential organ failure assessment (SOFA) score, and Simplified Acute Physiology Score (SAPS) II.

§Model 4 covariates were adjusted for sex, age, BMI, myocardial infarction, congestive heart failure, cerebrovascular disease, chronic pulmonary disease, diabetes with complications, renal disease, Charlson comorbidity index, SOFA score, SAPS II, heart rate, mean arterial pressure (MAP), respiratory rate, and peripheral oxygen saturation (SpO2).

ІІModel 5 covariates were adjusted for sex, age, BMI, myocardial infarction, congestive heart failure, cerebrovascular disease, chronic pulmonary disease, diabetes with complications, renal disease, Charlson comorbidity index, SOFA score, SAPS II, heart rate, MAP, respiratory rate, SpO2, hemoglobin, platelets, white blood cells, blood urea nitrogen, creatinine, glucose, potassium, lactate, partial pressure of oxygen: fraction of inspired oxygen ratio, Glasgow Coma Scale, and base excess.

Abbreviations: RDW, red blood cell distribution width; HR, hazard ratio; CI, confidence interval.

Ann Lab Med 2024;44:401~409 https://doi.org/10.3343/alm.2023.0345

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