pISSN 2234-3806eISSN 2234-3814
Table. 1.
Antifungal susceptibility of the Lichtheimia ornata isolate from this study and previously reported Lichtheimia spp. and their clinical information
| Antifungal agent | Time (hrs) assessed | MIC or MEC |
||
|---|---|---|---|---|
| L. ornata (this study) | L. ornata, previously reported in rhinocerebral mucormycosis [4] | L. ornata, previously reported [9] | ||
| Amphotericin B | 24/48 | 2/4 | 2/NA | 0.12/0.12 |
| Anidulafungin | 24/48 | 4/>8 | 4/32 | |
| Micafungin | 24/48 | >8/>8 | >256/NA | 32/32 |
| Caspofungin | 24/48 | >8/>8 | >16/NA | 32/32 |
| 5-flucytosine | 24/48 | >64/>64 | >64/NA | |
| Posaconazole | 24/48 | 1/1 | 2/NA | 0.25/0.25 |
| Voriconazole | 24/48 | >8/>8 | >16/NA | 16/16 |
| Itraconazole | 24/48 | 0.5/1 | 1/NA | 0.5/1 |
| Fluconazole | 24/48 | >256/>256 | >64/NA | |
| Clinical information | L. ornata (this study) | L. ornata, previously reported in rhinocerebral mucormycosis [4] | L. ornata, previously reported [9] |
|---|---|---|---|
| Age (yr)/sex | 67/F | 40/F | NA |
| Organ involvement | Lungs | Rhino-orbital-cerebral region | NA |
| Underlying condition | Acute lymphoblastic leukemia | Aplastic anemia, after allogeneic hematopoietic stem cell transplantation | NA |
| Diagnosis | Pulmonary mucormycosis | Rhinocerebral mucormycosis | NA |
| Treatment | Liposomal amphotericin B | Amphotericin B | NA |
| Outcome | Cured | Died | NA |
*Cut-off values for echinocandins (anidulafungin, micafungin and caspofungin) are interpreted as minimal effective concentration instead of minimal inhibitory concentration [7].
Abbreviations: MIC, minimal inhibitory concentration; MEC, minimal effective concentration (calculated for echinocandins); NA, not available; F, female.
Ann Lab Med 2024;44:371~374 https://doi.org/10.3343/alm.2023.0426
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