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Table. 3. Ten cases where either the individual or their family has a history of hemolysis
No. case* Age, yrs Sex G6PD activity,
U/g Hb
G6PD activity, % of normal G6PD genotype Occurrences of hemolysis Onset age of hemolysis occurred Trigger(s) Clinical manifestation Hospitalization Note
1 56 Male 0.86 5.5 c.1376G>T hemizygote 1 School age Sulfonamides, analgesic-antipyretic Blood in the urine Yes -
2 23 Male 1.09 7.0 c.1376G>T hemizygote 1 School age Fava beans Jaundice Yes -
3 33 Male 1.51 9.7 c.1388G>A hemizygote 1 School age Fava beans -§ Yes -
4 29 Male 2.29 14.7 c.95A>G hemizygote 1 Neonatal period - Neonatal jaundice No|| -
5 37 Female 4.26 27.5 c.1376G>T heterozygote 1 School age Fava beans -§ Yes -
6 56 Female 9.02 58.2 c.871G>A heterozygote 1 Preschool age Sulfonamides -§ No Her father has G6PD deficiency
7 37 Female 10.09 65.0 c.1376G>T heterozygote 1 Neonatal period - Neonatal jaundice No|| -
8 41 Female 6.22 40.1 c.1388G>A heterozygote 0 - - - - Her daughter: neonatal jaundice
9 41 Female 8.43 54.3 c.95A>G heterozygote 0 - - - - Her nephew: paleness after taking an analgesic-antipyretic
10 37 Female 10.18 65.6 c.1388G>A heterozygote 0 - - - - Her son: neonatal jaundice

*Patients 1–7 had hemolysis, whereas patients 8–10 showed no symptoms, but their relatives had hemolysis.

The G6PD activity (% of normal) is calculated as a percentage by dividing the G6PD (U/g Hb) result by the NMM2 value (15.51 U/g Hb).

Hospitalization was due to sudden acute hemolysis.

§Patients 3, 5, and 6 forgot their symptoms.

||Patients 4 and 7 underwent no additional hospitalization and had no symptoms of hemolysis after the last follow-up.

Abbreviations: G6PD, glucose-6-phosphate dehydrogenase; NMM2, normal male median in group 2.

Ann Lab Med 2024;44:487~496 https://doi.org/10.3343/alm.2023.0477

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