Fig. 1. Characteristics of CHIP variants in the Aβ-positive (N=43) and Aβ-negative (N=15) groups and forest plot of multivariate regression for the risk of brain Aβ deposition. (A) CHIP prevalence according to age. Bars indicate CHIP prevalence in different age groups. The line graph represents the cumulative prevalence of CHIP across the age groups. The absolute number of patients with CHIP and the total number of patients in each age group are displayed at the base of the graph. (B) CHIP prevalence according to gene. (C) Proportions of variant types in CHIP variants. (D) Percentages of different SNVs in CHIP variants. (E) VAFs of CHIP variants detected in the Aβ-positive and Aβ-negative groups. (F) Forest plot of multivariate logistic regression for the risk of brain Aβ deposition. Covariates included age, sex, presence of CHIP, and presence of the APOE ε4 allele.
Abbreviations: Aβ, β-amyloid; CHIP, clonal hematopoiesis of indeterminate potential; CI, confidence interval; OR, odds ratio; SNV, single-nucleotide variant; VAF, variant allele frequency.

Ann Lab Med 2024;44:576~580 https://doi.org/10.3343/alm.2024.0086