Fig. 3. Variant distribution, restratification, and OS analysis with different risk models. (A, C) Violin plots showing the number of variants as the risk groups changed when switching from the IPSS-R model to (A) the IPSS-M model or (C) the AIPSS-MDS model, affecting patient therapy. (B) Sankey plot depicting the percentage of patients restratified among the models. (D) Kaplan–Meier probability estimates of the OS for low- and high-risk groups of patients with available survival data. The AIPSS-MDS risk groups were defined based on the median risk score from the original training set by Mosquera, et al. [15]. Risk groups were defined using a risk-score cut-off of 3.5 for IPSS-R and a cut-off of 0 for IPSS-M. Each HR and associated P were calculated by setting the low-risk group as the reference.
Abbreviations: OS, overall survival; IPSS-R, International Prognostic Scoring System, revised version; IPSS-M, Molecular International Prognostic Scoring System; AIPSS-MDS, Artificial Intelligence Prognostic Scoring System for MDS; HR, hazard ratio; NA, not available; mo, months.

Ann Lab Med 2025;45:44~52 https://doi.org/10.3343/alm.2024.0089