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Table. 1.

Table 1 Patient clinical characteristics at CSF sampling time and CSF ctDNA detection

Case No.	Age (yrs)	Sex	Diagnosis	Clinical history of CNS involvement	Radiologic CNS involvement pattern	CSF cytology	CSF ctDNA	Survival
1	72	M	DLBCL, ABC type	RCHOP 6 cycles for stage I → Isolated CNS relapse	Leptomeninges	Negative	Not detected-	Dead
2	54	M	DLBCL, ABC type	RCHOP 6 cycles for stage 4 → Isolated CNS relapse	Parenchyma+Leptomeninges	Positive	Detected	Dead
3	41	M	DLBCL, ABC type	RCHOP 6 cycles for stage 1 → Isolated CNS relapse	Leptomeninges	Positive	Detected	Alive
4	34	M	Primary CNS DLBCL	Primary CNS involvement	Parenchyma	Negative	Detected	Alive
5	57	F	DLBCL, ABC type	RCHOP 6 cycles for stage 1 → Isolated CNS relapse	Parenchyma	Positive	Detected	Dead
6	39	F	DLBCL, GC type	RCHOP 6 cycles for stage 4 → Systemic relapse → ICED followed by ASCT → Systemic relapse with CNS involvement	Leptomeninges	Negative	Library construction failed	Dead
7	73	M	DLBCL, GC type	RCHOP 6 cycles for stage 3 → Isolated CNS relapse	Leptomeninges	Positive	Detected	Dead
8	61	M	DLBCL, ABC type	RCHOP 6 cycles for stage 2 → Isolated CNS relapse	Parenchyma	Positive	Not detected	Alive
9	40	M	DLBCL, GC type	RCHOP 3 cycles for stage 4 → Progression with CNS involvement	Leptomeninges	Positive	Detected	Dead
10	72	M	DLBCL, ABC type	RCHOP 6 cycles for stage 4 → Isolated CNS relapse	Leptomeninges	Negative	Detected	Dead
11	52	M	DLBCL, GC type	RCHOP 6 cycles for stage 4 → Systemic relapse with CNS involvement	Parenchyma+Leptomeninges	Negative	Not detected	Dead
12	72	M	Primary CNS DLBCL	Primary CNS involvement	Parenchyma	Negative	Detected	Alive
13	53	M	DLBCL, ABC type	RCHOP 2 cycles for stage 4 → Progression with CNS involvement	Parenchyma	Negative	Detected	Dead
14	73	F	DLBCL, GC type	RCHOP 3 cycles for stage 4 → Isolated CNS relapse	Parenchyma+Leptomeninges	Negative	Detected	Dead
15	71	M	Primary CNS DLBCL	Primary CNS involvement	Parenchyma+Leptomeninges	Negative	Detected	Dead
16	41	F	DLBCL, ABC type	RCHOP 6 cycles for stage 4 → Systemic relapse with CNS involvement	Parenchyma+Leptomeninges	Positive	Detected	Dead
17	68	F	DLBCL, ABC type	RCHOP 6 cycles for stage 4 → Isolated CNS relapse	Parenchyma	Negative	Detected	Dead

Abbreviations: CSF, cerebrospinal fluid; ctDNA; circulating tumor DNA; DLBCL, diffuse large B-cell lymphoma; ABC, activated B-cell like; GC, germinal center; CNS, central nervous system; RCHOP, rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone.

Ann Lab Med 2025;45:90~95 https://doi.org/10.3343/alm.2024.0257