Fig. 1. Characteristics of TP53 mutations in patients with MDS or AML. (A) Spectrum of TP53 mutations (numbers in circular discs are the numbers of TP53 mutations identified). (B) Types of TP53 mutations. (C) Distribution of the TP53 mutation VAF according to disease categories, presence of 17p loss, and a CK. (D) Proportions of 17p loss and a CK based on a 50% VAF threshold. (E) Status of 17p loss and CK according to the number of TP53 mutations.
Abbreviations: MDS, myelodysplastic neoplasm; VAF, variant allele frequency; CK, complex karyotype; ND, not determined.

Ann Lab Med 2025;45:160~169 https://doi.org/10.3343/alm.2024.0351