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Fig. 2. Mass spectra of N-glycan profiling using Matrix-assisted Laser Desorption Ionization Time-of-flight Mass Spectrometry following peptide-N-glycosidase F treatment. The mass spectra of samples from the patient (A) revealed an increase in mannose-rich glycans (upward black triangle) and a decrease in N-acetyl glucosamine-binding glycans (downward black triangle) compared with that in the healthy control (B). A hybrid-type N-glycan was observed at m/z 1913.7 (red), which is specific to patients with MAN1B1 deficiency. Green circles, mannose; yellow circles, galactose; blue squares, N-acetyl glucosamine; red triangles, fucose; and purple diamonds, sialic acid.

Ann Lab Med 2025;45:112~115 https://doi.org/10.3343/alm.2024.0226