Fig. 1. CD69 expression on T cells and their subsets in treatment-naive patients with CHB and HCs. (A) CD69 levels on CD3+, CD4+ and CD8+ T cells in patients with CHB and HCs. (B–C) CD69 levels on T cells and the subset cells in patients with CHB in the IT, IA, IC, and GZ phases and HCs. (D) CD69 MFI of CD3+, CD4+ and CD8+ T cells in patients with CHB and HCs. (E) CD69 MFI of T cells and their subsets in patients with CHB in the IT, IA, IC and GZ phases and HCs. None of the continuous variables conformed to the normal distribution. P-values were calculated using the Mann–Whitney U test. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.
Abbreviations: MFI, mean fluorescence intensity; CHB, chronic hepatitis B; HC, healthy control; IT, immune-tolerant; IA, immune-active; IC, inactive CHB; GZ, gray zone.

Ann Lab Med 2025;45:185~198 https://doi.org/10.3343/alm.2024.0178