Fig. 4. Correlation between CD69 and inhibitory molecule production by T cells. Levels of (A) PD-1, (B) CTLA-4, (C) LAIR-1, and (D) LAG-3 on CD3+, CD4+ and CD8+ T cells in the CD69^high and CD69^low groups, and correlations between these inhibitory molecules and CD69 levels on CD3+, CD4+, and CD8+ T cells. None of the continuous variables conformed to the normal distribution. Differences were analyzed using the Mann–Whitney U test. Spearman correlation was used for correlation analysis. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.
Abbreviations: PD-1, programmed death receptor 1; CTLA-4, cytotoxic T lymphocyte-associated antigen-4; ns, non-significant; LAIR-1, leukocyte-associated Ig-like receptor-1; LAG-3, lymphocyte activation gene-3.

Ann Lab Med 2025;45:185~198 https://doi.org/10.3343/alm.2024.0178