Fig. 1. CDRs and CCRs of chromosome 5q associated with MDS and AML. The distal CDR (CDR-1) is located at 5q33 and is associated with the deletion of RPS14 and 5q– syndrome. The proximal CDR (CDR-2) at 5q31 encompasses genes, including EGR1, CSNK1A1, and G3BP1, and is associated with aggressive MDS and AML. CRRs are shown in green. This figure was created with BioRender.com.
Abbreviations: MDS, myelodysplastic syndrome; CDR, commonly deleted region; CRR, commonly retained region; RPS14, ribosomal protein S14; EGR1, early growth response 1; CSNK1A1, casein kinase 1 alpha 1; G3BP1, G3BP stress granule assembly factor 1; NPM1, nucleophosmin 1; DDX41, DEAD-box helicase 41.

Ann Lab Med 2025;45:133~145 https://doi.org/10.3343/alm.2024.0477