Fig. 2. CDRs of chromosome 7q associated with MDS and AML. The CDR on chromosome 7q spans 7q21.13–7q36.3, with regions corresponding to bands 7q31.33, 7q34, and 7q35–7q36.1 deleted in the majority of cases [15]. Genes of interest in the pathogenesis of –7/del(7q) myeloid neoplasms include SAMD9/SAMD9L, CUX1, and EZH2. This figure was created with BioRender.com.
Abbreviations: MDS, myelodysplastic syndrome; CDR, commonly deleted region; SAMD9/SAMD9L, sterile alpha motif domain-containing 9/sterile alpha motif domain-containing 9-like; CUX1, cut-like homeobox 1; EZH2, enhancer of zeste 2 polycomb-repressive complex 2 subunit.

Ann Lab Med 2025;45:133~145 https://doi.org/10.3343/alm.2024.0477