Article

Letter to the Editor

Ann Lab Med 2020; 40(5): 431-434

Published online September 1, 2020 https://doi.org/10.3343/alm.2020.40.5.431

Copyright © Korean Society for Laboratory Medicine.

Successful Desensitization by Post-Centrifugal Plasma Filtration in Two Highly Sensitized Heart and Lung Transplant Recipients

Hyun-Ji Lee, M.D., Ph.D.1 , Kyung-Hwa Shin, M.D., Ph.D.2 , Hyung-Hoi Kim, M.D., Ph.D.2 , Hyung Gon Je, M.D., Ph.D.3 , Dohyung Kim, M.D.3 , Woo Hyun Cho, M.D., Ph.D.4 , Jeong Su Kim, M.D., Ph.D.5 , Soo Yong Lee, M.D., Ph.D.5 , and Hye Ju Yeo, M.D., Ph.D.4

1Department of Laboratory Medicine and Research, Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea; 2Department of Laboratory Medicine, Pusan National University Hospital, Busan, Korea; 3Department of Cardiovascular and Thoracic Surgery and Research, Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea; 4Department of Pulmonology and Critical Care Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea; 5Division of Cardiology, Department of Internal Medicine and Research, Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea

Correspondence to: Hyung-Hoi Kim, M.D., Ph.D.
Biomedical Research Institute, Pusan National University Hospital Clinical Trial Center (CTC), Department of Laboratory Medicine and Biomedical Informatics Unit of Pusan National University School of Medicine, 1-10 Ami-dong, Seo-gu, Busan 49241, Korea
Tel: +82-51-240-7418, Fax: +82-51-247-6560, E-mail: hhkim@pusan.ac.kr

Received: November 5, 2019; Revised: January 6, 2020; Accepted: March 3, 2020

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Fig. 1.

Changes in DSAs with desensitization treatment. (A) A heart transplant recipient (Case 1, Table 1) with preformed DSAs and (B) a lung transplant recipient (Case 2, Table 1) who underwent desensitization before donor matching.

Abbreviations: ATG, anti-thymocyte globulin; DSA, donor-specific antibody; IVIG, intravenous immunoglobulin; MFI, mean fluorescence intensity; PCPF, post-centrifugal plasma filtration; POD, postoperative day.


Baseline characteristics of the two patients with DSAs

CaseSexAge (yr)DiagnosisRecipientDonorDSA (initial MFI strength)Pre-transplantOutcome (days)





HLA
A
HLA
B
HLA
DR
HLA
A
HLA
B
HLA
DR
Class IClass IICumulative MFICDC (T/B)FCM (T/B)RejectionAlive/Dead
1F32Dilated cardiomyopathy11/2407/5404/0424/2451/5214/15B52 (9,135), B51 (2,484)DR14 (14,616) DR15 (8,800)35,035Positive/PositivePositive/PositiveAMR episodeAlive (1,774)

2F54Acute interstitial pneumonia33/3344/4407/1302/1113/4812/14A2 (2,752), B48 (7,093), B13 (3,079)12,924Negative/NegativePositive/PositiveNoAlive (1,474)

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