Article

Letter to the Editor

Ann Lab Med 2020; 40(6): 493-499

Published online November 1, 2020 https://doi.org/10.3343/alm.2020.40.6.493

Copyright © Korean Society for Laboratory Medicine.

Human Platelet Antigen Datasets for Malays, Chinese, and Indians in Peninsular Malaysia

Che Ghazali Norul Hajar, M.DSc.1 , Zulkifli Zefarina, M.D., M.Path.2 , Nor Suhaila Md. Riffin, M.D., M.Path.3 , Tuan Hulwani Tuan Mohammad, M.D., M.Path.4 , Mohd Nazri Hassan, M.D., M.Path.2 , Ameer Mohamed Dafalla, Ph.D.5 , Gehad ElGhazali, M.D., M.Path.6 , Geoffrey Keith Chambers, Ph.D.7 , and Hisham Atan Edinur, Ph.D.1

1School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia; 2Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia; 3Hospital Sultan Haji Ahmad Shah, Temerloh, Pahang, Malaysia; 4Hospital Seberang Jaya, Perai, Pulau Pinang, Malaysia; 5HLA Laboratory, National Cancer Institute, University of Gezira, Wad Medani, Sudan; 6Department of Immunology, Pathology and Laboratory Medicine Services, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates; 7School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand

Correspondence to: Hisham Atan Edinur, Ph.D.
School of Health Sciences Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Tel: +60 9-7677641, Fax: +60 9-7677515, E-mail: edinur@usm.my

Received: January 31, 2020; Revised: March 7, 2020; Accepted: May 21, 2020

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

HPA allele frequency distribution in the present and previous studies

Population(N)1a1b2a2b3a3b4a4b5a5b6a6b15a15b
Malays (present study)970.9850.0150.9690.0310.5100.4901.0000.0000.9900.0100.9900.0100.4790.521
Chinese (present study)771.0000.0000.9800.0200.5910.4101.0000.0000.9870.0130.9940.0060.5260.474
Indians (present study)470.9790.0210.9690.0310.5210.4791.0000.0000.9590.0410.9900.0100.3750.625
Banjar [3]301.0000.0000.9500.0500.6160.3840.9500.0500.9500.0500.9800.0200.4800.520
Bugis [3]371.0000.0001.0000.0000.5540.4461.0000.0000.9500.0500.9100.0900.6200.380
Champa [3]510.9800.0200.9700.0300.6770.3231.0000.0000.9900.0100.9800.0900.4800.520
Jawa [3]391.0000.0001.0000.0000.6280.3721.0000.0000.9600.0401.0000.0000.4500.550
Kelantan [3]351.0000.0000.9400.0600.5710.4291.0000.0001.0000.0000.9900.0100.4900.510
Orang Kanaq [4]111.0000.0001.0000.0000.8180.1821.0000.0001.0000.0001.0000.0000.9090.091
Batek [4]271.0000.0001.0000.0000.5000.5001.0000.0000.8520.1481.0000.0000.0001.000
Lanoh [4]251.0000.0001.0000.0000.6400.3601.0000.0001.0000.0001.0000.0000.2600.740
Kensiu [4]360.9580.0421.0000.0000.8750.1251.0000.0000.8470.1531.0000.0000.3610.639
Che Wong [4]261.0000.0001.0000.0000.4230.5771.0000.0000.7880.2121.0000.0000.5000.500
Semai [4]400.9880.0121.0000.0000.6710.3291.0000.0000.8900.1101.0000.0000.5240.476
Malays [6]2000.9750.0250.9630.0370.5030.4970.9950.0050.9500.0500.9930.0070.5150.485
Chinese [6]2001.0000.0000.9670.0330.5730.4270.9980.0020.9830.0170.9830.0170.4980.502
Indians [6]2000.8850.1150.9600.0400.6200.3800.9950.0050.9400.0600.9950.0050.4080.592

Homogeneity between pairs of population groups in Peninsular Malaysia

HPA-1

MalaysChineseIndiansBanjar [3]Bugis [3]Champa [3]Jawa [3]Kelantan [3]O. K. [4]Batek [4]Lanoh [4]Kensiu [4]C. W. [4]Semai [4]Malays [6]Chinese [6]Indians [6]
Malays*0.257NANA0.558NA0.5570.568NANANA0.340NANANANA<0.000
Chinese0.088*0.145NANA0.158NANANANANA0.032NA0.344NANA<0.000
Indians1.0000.294*0.5200.501NA0.4990.507NA0.5340.5440.6500.538NANANA0.004
Banjar [3]0.4410.0630.669*NA0.530NANANANANA0.241NANANANA0.003
Bugis [3]0.1841.0000.2540.085*0.508NANANANANA0.114NANANANA<0.000
Champa [3]0.2091.0000.3490.1931.000*0.5040.516NA0.539NA0.6450.545NANANA0.003
Jawa [3]0.1831.0000.2490.076NA1.000*NANANANA0.108NANANANA0.001
Kelantan [3]0.4530.0340.4501.0000.0520.1600.046*NANANA0.239NANANANA<0.000
O. K. [4]1.0001.0001.0000.551NA1.000NA0.557*NANANANANANANA0.162
Batek [4]0.3401.0000.5460.239NA1.000NA0.127NA*NA0.252NANANANA0.004
Lanoh [4]0.3431.0000.5450.241NA1.000NA0.135NANA*0.263NANANANA0.008
Kensiu [4]0.1901.0000.2550.088NA1.000NA0.052NANANA*NANANANA0.159
C.W [4]0.3381.0000.2550.242NA1.000NA0.131NANANANA*NANANA0.005
Semai [4]0.1781.0000.2490.076NA1.000NA0.043NANANANANA*NANA0.004
Malays [6]0.8120.0351.0000.713NA0.079NA0.4980.6230.2230.3860.1390.2300.086*NA<0.000
Chinese [6]0.8570.2000.7820.4920.3430.2720.3520.3600.7050.4390.6600.6620.3500.5430.857*<0.000
Indians [6]1.0000.1061.0000.5420.2690.1960.2800.4260.6410.4590.4380.2710.4590.2771.0000.836*
HPA-2

HPA-3

MalaysChineseIndiansBanjar [3]Bugis [3]Champa [3]Jawa [3]Kelantan [3]O. K. [4]Batek [4]Lanoh [4]Kensiu [4]C. W. [4]Semai [4]Malays [6]Chinese [6]Indians [6]
Malays*0.1320.2510.186<0.0010.0020.1160.6000.0160.8710.038<0.0010.4190.0160.7110.1900.018
ChineseNA*0.5220.960<0.0010.2630.8990.8910.1920.1930.467<0.0010.0480.3760.1360.8720.784
IndiansNANA*0.5840.0190.1300.4020.5260.0600.2360.381<0.0010.1390.3760.4340.3880.297
Banjar [3]0.0130.0190.075*0.0140.6381.0000.8040.3320.2060.7220.0030.0630.6750.2390.7610.297
Bugis [3]NANANA0.085*0.0250.0060.0010.016<0.0010.160<0.001<0.0010.002<0.001<0.0010.955
Champa [3]NANANA0.047NA*0.6020.1860.5720.0140.9000.0120.0030.5900.0010.0600.009
Jawa [3]NANANA0.077NANA*0.7000.3460.150.6610.0020.0380.7430.1050.6580.099
Kelantan [3]NANANA0.095NANANA*0.1050.6050.337<0.0010.1720.3480.5540.9690.964
O. K. [4]NANANA0.551NANANANA*0.0250.3730.4670.0030.6720.0080.1010.694
Batek [4]NANANA0.238NANANANANA*0.050<0.0010.6670.0480.6300.2800.216
Lanoh [4]NANANA0.240NANANANANANA*0.0090.0150.4480.0560.2570.279
Kensiu [4]NANANA0.089NANANANANANANA*<0.0010.020<0.001<0.001<0.001
C.W [4]NANANA0.242NANANANANANANANA*0.0060.3410.0690.009
Semai [4]NANANA0.073NANANANANANANANANA*0.0080.1840.523
Malays [6]NANANA0.002NANANANANANANANANANA*0.1270.009
Chinese [6]NANANANANANANANANANANANANANA0.368*0.396
Indians [6]NANANANANANANANANANANANANANA0.368*
HPA-4

HPA-5

MalaysChineseIndiansBanjar [3]Bugis [3]Champa [3]Jawa [3]Kelantan [3]O. K. [4]Batek [4]Lanoh [4]Kensiu [4]C. W. [4]Semai [4]Malays [6]Chinese [6]Indians [6]
Malays*1.0000.0931.0000.0491.0000.1421.0001.000<0.001<0.0011.000<0.0011.0000.7230.7230.008
Chinese1.000*0.2001.0000.0881.0000.3331.0001.000<0.001<0.0011.000<0.0010.5461.0001.0000.038
Indians1.0001.000*0.1540.7230.1931.0000.1341.0000.0230.0100.2920.0030.1250.2330.2290.834
Banjar [3]0.5560.4841.000*0.1221.0000.254NANA0.001<0.001NA<0.001NA0.5960.5980.203
Bugis [3]0.0010.0010.0180.068*0.1580.7090.1160.5590.0990.0450.1400.0120.0490.0710.0711.000
Champa [3]1.0001.0001.0001.0000.009*0.3181.0001.000<0.001<0.0011.000<0.0011.0001.0001.0000.098
Jawa [3]0.1430.1090.3210.6280.1900.312*0.2411.0000.0420.0180.2710.0040.1150.2140.2120.813
Kelantan [3]1.0001.0001.0000.4590.0111.0000.240*NA<0.001<0.001NA<0.001NA0.5970.5950.093
O. K. [4]1.0001.0001.0001.0000.1771.0001.000NA*0.074NA0.0460.018NA1.0001.0000.635
Batek [4]1.0001.0001.0001.0000.0161.0000.267NANA*0.0041.0000.568<0.001<0.001<0.0000.028
Lanoh [4]1.0001.0001.0001.0000.0361.0000.275NANANA*0.001<0.001NA1.0001.0000.242
Kensiu [4]1.0001.0001.0000.4550.0101.0000.241NANANANA*0.589<0.001<0.001<0.0000.013
C.W [4]1.0001.0001.0001.0000.0351.0000.265NANANANANA*<0.001<0.001<0.0000.002
Semai [4]1.0001.0001.0000.4280.0041.0000.113NANANANANANA*0.6040.6010.295
Malays [6]0.7220.4481.0001.0000.0021.0000.211NANANANANANANA*1.0000.003
Chinese [6]0.7240.4501.0001.0000.0021.0000.210NANANANANANANA1.000*0.003
Indians [6]0.6021.0000.4740.344<0.0010.4920.032NANANANANANANA0.1690.175*
HPA-6

HPA-15

MalaysChineseIndiansBanjar [3]Bugis [3]Champa [3]Jawa [3]Kelantan [3]O. K. [4]Batek [4]Lanoh [4]Kensiu [4]C. W. [4]Semai [4]Malays [6]Chinese [6]Indians [6]
Malays*0.5030.2170.0870.0490.4070.7320.007<0.001<0.0010.0190.1440.0130.2550.6870.9040.176
Chinese**0.0330.0220.0650.1270.5210.001<0.001<0.0010.0020.0470.0700.0910.7230.6380.012
Indians***0.1200.0070.3080.3750.029<0.001<0.0010.4430.6060.0030.1470.0410.0700.866
Banjar [3]****0.3000.6260.0460.8620.013<0.0010.0800.020<0.0010.7940.0500.0490.109
Bugis [3]*****0.2600.0310.1160.080<0.0010.0020.003<0.0010.4750.0770.0450.004
Champa [3]******0.2470.2270.002<0.0010.0630.082<0.0010.8620.2400.2570.340
Jawa [3]*******0.006<0.001<0.0010.0570.5410.0890.1100.4480.6030.309
Kelantan [3]********0.013<0.0010.0310.003<0.0010.4280.0020.6030.011
O. K. [4]*********<0.001<0.001<0.001<0.001<0.0010.001<0.001<0.001
Batek [4]**********<0.001<0.001<0.001<0.001<0.001<0.001<0.001
Lanoh [4]***********0.352<0.0010.0330.0020.0030.183
Kensiu [4]************0.0260.0300.0370.0660.323
C.W [4]*************<0.0010.0100.0090.001
Semai [4]**************0.1880.1720.136
Malays [6]***************0.8750.006
Chinese [6]****************0.014
Indians [6]*****************

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