Letter to the Editor
Ann Lab Med 2021; 41(5): 502-503
Published online September 1, 2021 https://doi.org/10.3343/alm.2021.41.5.502
Copyright © Korean Society for Laboratory Medicine.
The Stability of Blood Gas Parameters Depends on Leukocyte Counts
1CHU Lille, Service de Biochimie Automatisée Protéines, Lille, France; 2CHU Lille, Service d’Hormonologie, Métabolisme, Nutrition et Oncologie, Lille, France
Correspondence to: Guillaume Grzych, Pharm.D., Ph.D.
Laboratory of Biochemistry, Biology and Pathology Center, Lille University Hospital, Pr J. Leclercq Boulevard, 59037, Lille Cedex, France
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
In cases of low pH, in the absence of clinical signs and/or an obvious cause of a spurious pH value, we suggest checking leukocyte count. Spurious pH values can be caused by a delay (longer than 30 minutes) between sample collection and analysis, EDTA contamination, or inappropriate sample transport [1, 5]. When the leukocyte count is >15×109/L, we suggest using point-of-care testing (POCT) to measure blood gas parameters to avoid spurious results (Fig. 1). The use of a POCT device reduces preanalytical transport-related issues and the time to measurement, thus reduces the impact of leukocyte counts on the stability of blood gas parameters [6, 7]. We wanted to provide a reminder of the significant impact of leukocyte counts on the stability of blood gas parameters and recommend considering leukocyte measurement in future studies and clinical practice.
Figure 1. Validation algorithm of blood gas parameters in case of acidosis.
Vaudran L and Pekar JD wrote the paper and Maboudou P and Grzych G co-supervised.
The authors have no conflict of interest to disclose.
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