Case Report

Korean J Clin Pathol 1992; 12(3): 311-315

Published online June 1, 1992

Copyright © Korean Society for Laboratory Medicine.

A Case of Granular Acute Lymphoblastic Leukemia

윤미애 · 김윤정 · 최삼임


Background :Granules in blasts usually are considered a characteristic of acute myelogenous leukemia. However, recent several reports have described acute lymphoblastic leukemiacALL) that contained azurophilic cytoplasmic granules. This finding may lead to an incorrect diagnosis of acute myelogenous leukemia, especially in older patients. The granules are negative for both peroxidase and Sudan black B, but give positive granular reaction for acid phosphatase and nonspecific esterase. The nature and prognostic significance of the cytoplasmic granules remain to be determined. Although only two cases of granular ALL have been reported in literature in Korea, it might occur more frequently than the frequency that paucity of reports suggest, showing the potential for misdiagnosis and should be more carefully recognized from now on. We report a case of granular ALL in 51-year-old woman. Method : Result : Conclusion :

Keywords: Granules, Granular ALL, Acute Lymphoblastic Leukemia