Case Report

Korean J Clin Pathol 2000; 20(6): 543-547

Published online December 1, 2000

Copyright © Korean Society for Laboratory Medicine.

A Case of Adult Neuroblastoma Involving Bone Marrow



Background :Neuroblastoma, which originates in the sympathetic division of the autonomic nervous system, is the most common extracranial solid malignancy in childhood but rarely occurs in adulthood. Only one case of neuroblastoma has been reported in Korean adult. The authors recently experienced a case of neuroblastoma originating from the retroperitoneal cavity with metastasis to the bone marrow and neck. A 29-year-old male was admitted at Inha University Hospital because of abdominal pain and back pain. The patient had a past history of chemotherapy for retroperitoneal tumor in a general hospital 4 years ago. In biochemical test, neuron specific enolase (NSE) was above 260 ng/mL and urine vanillylmandelic acid (VMA) was positive. Immunohistochemical stainings of bone marrow sections, showed positive reactions for NSE, chromogranin, and synaptophysin, however, revealed negative reactions for MIC2, vimentin, and mixed keratin. Pathologic examination showed the characteristic findings of neuroblastoma. We report this case with a review of literature. Method : Result : Conclusion :

Keywords: Neuroblastoma, Adult, Bone marrow, Korean