Original Article

Korean J Lab Med 2011; 31(3): 162-166

Published online July 1, 2011

Copyright © Korean Society for Laboratory Medicine.

Leptin:Adiponectin Ratio and Metabolic Syndrome in the General Japanese Population

Kazuhiko Kotani, M.D.1,2 and Naoki Sakane, M.D.1

Department of Preventive Medicine1, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto; Department of Clinical Laboratory Medicine2, Jichi Medical University, Shimotsuke-City, Tochigi, Japan

Correspondence to: Kazuhiko Kotani, M.D.
Department of Preventive Medicine and Diabetes Education Clinical Research Institute for Endocrine and Metabolic Disease National Hospital Organization Kyoto Medical Center Fushimi-ku, Kyoto 612-8555, Japan
Tel: +81-756-41-9161, Fax: +81-756-45-2781, E-mail:

Received: September 24, 2010; Revised: March 18, 2011; Accepted: May 11, 2011

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background: Circulating leptin:adiponectin ratio (L:A) is a potential surrogate marker for cardiometabolic diseases; however, the relationship of the L:A with the occurrence of metabolic syndrome (MetS) has not yet been fully explored in the general Japanese population.
Methods: We enrolled 678 Japanese subjects (208 men and 470 women, mean age: 58.8±14.4 [SD] yr; mean body mass index: 23.6±3.3 kg/m2) in this study, and determined their MetS status by using the National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP) recommendations with minor modifications for the Japanese population. Biochemical markers such as leptin and adiponectin present in blood were measured. The statistical analyses performed were gender-based.
Results: The L:A in subjects with MetS was significantly higher than that in subjects without MetS, regardless of gender. The L:A also showed a significant and gradual increase corresponding to the increase in the number of components of MetS present in both the genders (trend P<0.01). The cut-off level of the L:A to detect MetS was 0.59 (sensitivity: 0.72, specificity: 0.70) in men and 1.04 (sensitivity: 0.72, specificity: 0.69) in women.
Conclusions: These results suggest that the L:A can serve as a clinically useful marker for detecting MetS characteristics in the general Japanese population. The clinical application of this laboratory index for detecting MetS should be assessed in future studies.

Keywords: Adipocytokine, Adiponectin, Leptin, Metabolic syndrome