Original Article

Ann Lab Med 2012; 32(5): 339-344

Published online September 1, 2012

Copyright © Korean Society for Laboratory Medicine.

Changes in the Levels of Interleukins 6, 8, and 10, Tumor Necrosis Factor Alpha, and Granulocyte-colony Stimulating Factor in Korean Burn Patients: Relation to Burn Size and Postburn Time

Hyun Soo Kim, M.D.1, Jong-Hyun Kim, M.D.2, Haejun Yim, M.D.2, and Dohern Kim, M.D.2

Departments of Laboratory Medicine1, General Surgery2, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea

Correspondence to: Jong-Hyun Kim
Hangang Sacred Heart Hospital, Hallym University College of Medicine, 94-200 Youngdungpo-dong, Youngdungpo-gu, Seoul 150-179, Korea
Tel: +82-2-2639-5446
Fax: +82-2-2678-4386

Received: January 26, 2012; Revised: June 8, 2012; Accepted: July 6, 2012

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background: Major burn injury induces an inflammatory response that is accompanied by the release of various cytokines. We investigated the gradual changes in the levels of proinflammatory and anti-inflammatory cytokines following burn injury and determined the relationship between these levels and burn size in adult Korean patients with burn injury. Methods: Blood samples from 9 healthy controls and 60 Korean burn patients were collected on days 1, 3, 7, 14, and 21 after burn injury, and concentrations of interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, and granulocyte-colony stimulating factor (GCSF) were measured. Burn patients were divided into 3 groups according to burn size (15-30%, 31-50%, >50% total body surface area), and the concentrations of the cytokines were compared between these groups and the control group over 3 weeks. Results: Compared to their levels in controls, IL-6, IL-8, IL-10, TNF-α, and G-CSF levels in burn patients were significantly higher during the observation period. Median concentrations of IL-8, IL-10, and G-CSF at each time point increased with burn size, although peak levels and time to peak levels of these cytokines differed from patient to patient. Conclusions: These findings indicate that IL-6, IL-8, IL-10, TNF-α, and G-CSF are important mediators in inflammatory changes after burn injury; however, various factors, including burn size, may influence the concentrations of these cytokines.

Keywords: Burns, Cytokines, Body surface area, Time