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In Vitro Fluconazole and Voriconazole Susceptibilities of Candida Bloodstream Isolates in Korea: Use of the CLSI and EUCAST Epidemiological Cutoff Values
2013; 33(3): 167-173
Article
Brief Communication
Ann Lab Med 2012; 32(6): 426-428
Published online November 1, 2012 https://doi.org/10.3343/alm.2012.32.6.426
Copyright © Korean Society for Laboratory Medicine.
Antifungal Susceptibility to Amphotericin B, Fluconazole, Voriconazole, and Flucytosine in Candida Bloodstream Isolates from 15 Tertiary Hospitals in Korea
Sook-In Jung, M.D.1, Jong Hee Shin, M.D.2, Hyun-Jung Choi, M.D.2, Min-Young Ju, M.S.2, Soo-Hyun Kim, M.D.2, Wee Gyo Lee, M.D.3, Yeon-Joon Park, M.D.4, and Kyungwon Lee, M.D.5, for the Korean Study Group for Candidemia
Departments of Internal Medicine1 and Laboratory Medicine2, Chonnam National University Medical School, Gwangju; Department of Laboratory Medicine3, Ajou University College of Medicine, Suwon; Department of Laboratory Medicine4, The Catholic University of Korea College of Medicine, Seoul; Department of Laboratory Medicine and Research Institute of Bacterial Resistance5, Yonsei University College of Medicine, Seoul, Korea
Correspondence to: Jong Hee Shin
Department of Laboratory Medicine, Chonnam National University Medical School, 671 Jebong-ro, Dong-gu, Gwangju 501-757, Korea
Tel: +82-62-220-5342
Fax: +82-62-224-2518
E-mail: shinjh@chonnam.ac.kr
Received: June 7, 2012; Revised: June 28, 2012; Accepted: September 10, 2012
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The in vitro antifungal susceptibility of 636 Candida bloodstream isolates collected from 15 tertiary hospitals in Korea was determined using the Vitek-2 yeast susceptibility system (bioMérieux, France). Overall susceptibility rates were 98.1%, 95.9%, 99.1%, and 97.3% for amphotericin B, fluconazole, voriconazole, and flucytosine, respectively. The results show that the rates of resistance to 4 antifungal drugs remain low among Candida bloodstream isolates in Korea.
Keywords: Candida, Amphotericin B, Flucytosine, Fluconazole, Voriconazole