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Role of Plasma Exchange in ABO-incompatible Kidney Transplantation
2012; 32(4): 283-288
Article
Original Article
Ann Lab Med 2015; 35(5): 506-509
Published online September 1, 2015 https://doi.org/10.3343/alm.2015.35.5.506
Copyright © Korean Society for Laboratory Medicine.
Therapeutic Plasma Exchange Using the Spectra Optia Cell Separator Compared With the COBE Spectra
Do-kyun Kim, M.D.1, Sinyoung Kim, M.D.1, Seok Hoon Jeong, M.D.1, Hyun Ok Kim, M.D.1, and Hyung Jik Kim, M.D.2
Department of Laboratory Medicine1, Yonsei University College of Medicine, Seoul; Department of Internal Medicine and Kidney Research Institute2, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
Correspondence to: Hyung Jik Kim
Department of Internal Medicine and Kidney Research Institute, Hallym University Sacred Heart Hospital, 22 Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang 431-796, Korea
Tel: +82-31-380-3702
Fax: +82-31-386-2269
E-mail: hyung@hallym.or.kr
Received: October 22, 2014; Revised: January 23, 2015; Accepted: May 21, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: The Spectra Optia (SPO) is a novel continuous-flow centrifugal apheresis system based on the COBE Spectra (CSP) platform. There have been few attempts to validate the advantages of the SPO. We performed a retrospective study comparing the two cell separators for therapeutic plasma exchange (TPE) procedures in kidney transplant (KT) patients and seeing efficacy and safety.
Methods: We analyzed 720 TPE procedures performed between August 2012 and July 2014. Procedures included desensitization TPE before KT and TPE for the management of acute and chronic antibody-mediated graft rejection. Demographic characteristics, operational TPE variables, and laboratory data were analyzed.
Results: Demographic characteristics for the SPO (n=389) and CSP (n=331) groups did not differ significantly. The procedure time to exchange one plasma volume was 94.2±10.3 min in the SPO group and 100.4±11.2 min in the CSP group (P<0.001). The plasma removal efficiency (PRE) was 92.5±4.9% in the SPO group and 83.2±3.7% in the CSP group (P<0.001). There were no significant differences across the two apheresis systems for changes in hematologic parameters.
Conclusions: Compared with the CSP, the SPO was associated with an improved PRE and a shorter procedure time to exchange one plasma volume. Our results in KT patients show that the SPO is superior to the CSP in TPE procedures.
Keywords: Apheresis, Plasma exchange, Kidney transplantation, Efficacy