Original Article

Ann Lab Med 2015; 35(5): 506-509

Published online September 1, 2015

Copyright © Korean Society for Laboratory Medicine.

Therapeutic Plasma Exchange Using the Spectra Optia Cell Separator Compared With the COBE Spectra

Do-kyun Kim, M.D.1, Sinyoung Kim, M.D.1, Seok Hoon Jeong, M.D.1, Hyun Ok Kim, M.D.1, and Hyung Jik Kim, M.D.2

Department of Laboratory Medicine1, Yonsei University College of Medicine, Seoul; Department of Internal Medicine and Kidney Research Institute2, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea

Correspondence to: Hyung Jik Kim
Department of Internal Medicine and Kidney Research Institute, Hallym University Sacred Heart Hospital, 22 Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang 431-796, Korea
Tel: +82-31-380-3702
Fax: +82-31-386-2269

Received: October 22, 2014; Revised: January 23, 2015; Accepted: May 21, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background: The Spectra Optia (SPO) is a novel continuous-flow centrifugal apheresis system based on the COBE Spectra (CSP) platform. There have been few attempts to validate the advantages of the SPO. We performed a retrospective study comparing the two cell separators for therapeutic plasma exchange (TPE) procedures in kidney transplant (KT) patients and seeing efficacy and safety.
Methods: We analyzed 720 TPE procedures performed between August 2012 and July 2014. Procedures included desensitization TPE before KT and TPE for the management of acute and chronic antibody-mediated graft rejection. Demographic characteristics, operational TPE variables, and laboratory data were analyzed.
Results: Demographic characteristics for the SPO (n=389) and CSP (n=331) groups did not differ significantly. The procedure time to exchange one plasma volume was 94.2±10.3 min in the SPO group and 100.4±11.2 min in the CSP group (P<0.001). The plasma removal efficiency (PRE) was 92.5±4.9% in the SPO group and 83.2±3.7% in the CSP group (P<0.001). There were no significant differences across the two apheresis systems for changes in hematologic parameters.
Conclusions: Compared with the CSP, the SPO was associated with an improved PRE and a shorter procedure time to exchange one plasma volume. Our results in KT patients show that the SPO is superior to the CSP in TPE procedures.

Keywords: Apheresis, Plasma exchange, Kidney transplantation, Efficacy