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Update on Procalcitonin Measurements
2014; 34(4): 263-273
Article
Original Article
Ann Lab Med 2015; 35(6): 570-577
Published online November 1, 2015 https://doi.org/10.3343/alm.2015.35.6.570
Copyright © Korean Society for Laboratory Medicine.
Soluble ST2 Has a Prognostic Role in Patients With Suspected Sepsis
Mina Hur, M.D.1, Hanah Kim, M.D.1, Hyun Jeong Kim, M.D.1, Hyun Suk Yang, M.D.2, Laura Magrini, M.D.3, Rossella Marino, M.D.3, Patrizia Cardelli, M.D.4, and Salvatore Di Somma, M.D.3; on behalf of GREAT Network
Departments of Laboratory Medicine1 and Internal Medicine2, Konkuk University School of Medicine, Seoul, Korea; Departments of Medical-Surgery Sciences and Translational Medicine3 and Clinical and Molecular Medicine4, School of Medicine and Psychology, ‘Sapienza’ University, Sant’ Andrea Hospital, Rome, Italy
Correspondence to: Salvatore Di Somma
Department of Medical-Surgery Sciences and Translational Medicine, University La Sapienza Rome, Sant’ Andrea Hospital, Via di Grottarossa 1035/1039 00189 Rome, Italy
Tel: +39-0633775581
Fax: +39-0633775890
E-mail: salvatore.disomma@uniroma1.it
This manuscript is based on a contribution at the GREAT Congress 2014.
Received: April 9, 2015; Revised: June 11, 2015; Accepted: July 23, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Soluble suppression of tumorigenicity 2 (sST2) has emerged as a novel biomarker for heart failure, and serum sST2 concentrations could be increased in inflammatory diseases. We explored whether sST2 is related to cardiac dysfunction/failure and has a prognostic role in patients with suspected sepsis. Methods: In a total of 397 patients with suspected sepsis, sST2 concentrations were measured by using the Presage ST2 Assay (Critical Diagnostics, USA). sST2 concentrations were analyzed according to procalcitonin (PCT) concentrations, cardiovascular subscores of the sepsis-related organ failure assessment (SOFA) score, and clinical outcomes. Results: sST2 concentrations were increased significantly according to the five groups of PCT concentrations and cardiovascular subscores of the SOFA score (P<0.000001 and P=0.036, respectively). In-hospital mortality was significantly higher among patients with sST2 concentrations above 35 ng/mL (P=0.0213) and among patients with increased concentrations of both sST2 and PCT (P=0.0028). Conclusions: sST2 seems to be related to both cardiac dysfunction/failure and severity in sepsis. Measurement of sST2 and PCT in combination would be useful for risk stratification and prognosis prediction in patients with suspected sepsis.
Keywords: Soluble suppression of tumorigenicity 2, Sepsis, Prognosis, Procalcitonin