Review Article l 01 November 2021

Second-Line Tests in the Diagnosis of Adrenocorticotropic Hormone-Dependent Hypercortisolism

Silvia Pinelli, M.D., Mattia Barbot et al.

Ann Lab Med 2021; 41: 521-531
Cushing’s syndrome (CS) is a rare disease caused by chronic and excessive cortisol secretion. When adrenocorticotropin hormone (ACTH) is measurable, autonomous adrenal cortisol secretion could be reasonably ruled out in a differential diagnosis of ...

Keywords: Cushing’s syndrome, Pituitary adenoma, Ectopic ACTH secretion, Differential diagnosis

Review Article l 01 November 2021

Early Laboratory Preparedness of the Korea Disease Control and Prevention Agency and Response to Unknown Pneumonia Outbreak from Wuhan, China, in January 2020

Il-Hwan Kim, Ph.D., Byung-Hak Kang et al.

Ann Lab Med 2021; 41: 532-539
We report the response process of the Laboratory Analysis Task Force (LATF) for Unknown Disease Outbreaks (UDOs) at the Korea Disease Control and Prevention Agency (KDCA) during January 2020 to coronavirus disease 2019 (COVID-19), which developed as ...

Keywords: Unknown disease outbreak, Korea Disease Control and Prevention Agency, Diagnostic algorithm, COVID-19, Severe acute respiratory syndrome (SARS)-CoV-2

Review Article l 01 November 2021

Biomarkers for Prognosis and Treatment Response in COVID-19 Patients

Giulia Bivona, M.D., Luisa Agnello et al.

Ann Lab Med 2021; 41: 540-548
During a severe infection such as coronavirus disease 2019 (COVID-19), the level of almost all analytes can change, presenting a correlation with disease severity and survival; however, a biomarker cannot be translated into clinical practice for trea...

Keywords: Biomarkers, Coronavirus, COVID-19, Predictive value, Severity

Review Article l 01 November 2021

Application of Single-Domain Antibodies (“Nanobodies”) to Laboratory Diagnosis

Tahir S. Pillay, MBChB., Ph.D. and Serge Muyldermans et al.

Ann Lab Med 2021; 41: 549-558
Antibodies have proven to be central in the development of diagnostic methods over decades, moving from polyclonal antibodies to the milestone development of monoclonal antibodies. Although monoclonal antibodies play a valuable role in diagnosis, the...

Keywords: Single-domain antibodies, Nanobodies, Monoclonal antibodies, Laboratory diagnosis

Review Article l 01 March 2021

Role of Genetic Variants and Gene Expression in the Susceptibility and Severity of COVID-19

Sarita Choudhary, M.D., Karli Sreenivasulu et al.

Ann Lab Med 2021; 41: 129-138
Since its first report in December 2019, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly emerged as a pandemic affecting nearly all countries worldwide. As the COVID-19 pandemic...

Keywords: Angiotensin-converting enzyme 2 (ACE2) variants, Transmembrane protease, Serine 2 (TMPRSS2), Epigenetics, COVID-19, SARS-CoV-2 infection

Review Article l 01 March 2021

Sustainability in Healthcare: Perspectives and Reflections Regarding Laboratory Medicine

Aroa Molero, Michele Calabrò, Maguelone Vignes et al.

Ann Lab Med 2021; 41: 139-144
Healthcare structures serve to protect and improve public health; however, they can have negative effects on human well-being and the environment. Thus, sustainability is an important target in a rapidly changing healthcare environment. We analyzed t...

Keywords: Healthcare, Sustainability, Environment, Laboratory medicine

Review Article l 01 January 2021

Biomarker-Guided Risk Assessment for Acute Kidney Injury: Time for Clinical Implementation?

Christian Albert, M.D., Michael Haase et al.

Ann Lab Med 2021; 41: 1-15
Acute kidney injury (AKI) is a common and serious complication in hospitalized patients, which continues to pose a clinical challenge for treating physicians. The most recent Kidney Disease Improving Global Outcomes practice guidelines for AKI have r...

Keywords: Acute kidney injury, AKI phenotypes, Neutrophil gelatinase-associated lipocalin, Subclinical AKI, Preclinical AKI, Kidney biomarker, Serum creatinine, Kidney risk prediction, Cell cycle arrest biomarker

Review Article l 01 January 2021

Clinical Utility of Mac-2 Binding Protein Glycosylation Isomer in Chronic Liver Diseases

Nobuharu Tamaki, M.D., Ph.D. et al.

Ann Lab Med 2021; 41: 16-24
An accurate evaluation of liver fibrosis is clinically important in chronic liver diseases. Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel serum marker for liver fibrosis. In this review, we discuss the role of M2BPGi in diagnosing li...

Keywords: Mac-2 binding protein glycosylation isomer, Liver fibrosis, Threshold, Hepatocellular carcinoma, Chronic hepatitis C, Chronic hepatitis B, Sustained virologic response, Nonalcoholic fatty liver disease

Review Article l 01 January 2021

Application of Next Generation Sequencing in Laboratory Medicine

Yiming Zhong, Ph.D, Feng Xu et al.

Ann Lab Med 2021; 41: 25-43
The rapid development of next-generation sequencing (NGS) technology, including advances in sequencing chemistry, sequencing technologies, bioinformatics, and data interpretation, has facilitated its wide clinical application in precision medicine. T...

Keywords: Next-generation sequencing, Oncology, Constitutional disorders, Infectious diseases

Journal Information November, 2021
Vol.41 No.6
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