Review Article l 01 September 2022

Unreliable Automated Complete Blood Count Results: Causes, Recognition, and Resolution

Gene Gulati, Ph.D., Guldeep Uppal et al.

Ann Lab Med 2022; 42: 515-530
Automated hematology analyzers generate accurate complete blood counts (CBC) results on nearly all specimens. However, every laboratory encounters, at times, some specimens that yield no or inaccurate result(s) for one or more CBC parameters even whe...

Keywords: Blood cell counts, Automated analyzer, Specimen handling, Problem solving

Review Article l 01 September 2022

Review of the Use of Liquid Chromatography-Tandem Mass Spectrometry in Clinical Laboratories: Part II–Operations

Brian A. Rappold, B.S.

Ann Lab Med 2022; 42: 531-557
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is increasingly utilized in clinical laboratories because it has advantages in terms of specificity and sensitivity over other analytical technologies. These advantages come with additional re...

Keywords: Liquid chromatography-tandem mass spectrometry, Operations, Quality control, Troubleshooting, Validation, Verification, Calibration

Review Article l 01 May 2022

Myelodysplastic Syndromes with Bone Marrow Fibrosis: An Update

Akriti G. Jain, M.D., Ling Zhang et al.

Ann Lab Med 2022; 42: 299-305
Myelodysplastic syndrome (MDS) is a diverse hematological malignancy with a wide spectrum of presentations and implications. Treatment strategies for patients with MDS heavily rely on prognostic scoring systems, such as the revised international prog...

Keywords: Myelodysplastic syndrome, Bone marrow fibrosis, International prognostic scoring system, Allogeneic stem cell transplantation

Review Article l 01 May 2022

Current State of Blood Management Services in Korea

Hyun Ok Kim, M.D., Ph.D.

Ann Lab Med 2022; 42: 306-313
Blood is lifesaving; however, it can neither be limitlessly acquired nor artificially produced. The supply and use of blood, as an invaluable biological commodity, necessitate systematic and rational management under governmental guidance to ensure s...

Keywords: Blood management, Service data, Korea

Review Article l 01 May 2022

Current Issues, Challenges, and Future Perspectives of Genetic Counseling in Korea

Namhee Kim, M.D., Sun-Young Kong et al.

Ann Lab Med 2022; 42: 314-320
Genetic testing has become increasingly integrated into all areas of healthcare, and complex genetic testing usage continues to grow; thus, the demand for genetic counseling (GC) is likely to increase. However, it is unclear whether the current clini...

Keywords: Genetic counseling, Genetic services, Specialists, Healthcare system, Policy

Review Article l 01 May 2022

Promotion to Top-Tier Journal and Development Strategy of the Annals of Laboratory Medicine for Strengthening its Leadership in the Medical Laboratory Technology Category: A Bibliometric Study

Sun Huh, M.D., Ph.D.

Ann Lab Med 2022; 42: 321-330
Background: A bibliometric analysis of the Annals of Laboratory Medicine (ALM) was performed to understand its position in the medical laboratory technology category and to suggest a developmental strategy. Methods: Journal metrics, including the num...

Keywords: Bibliometrics, Journal impact factor, Medical laboratory technology, Annals of Laboratory Medicine

Review Article l 01 March 2022

Review of the Use of Liquid Chromatography-Tandem Mass Spectrometry in Clinical Laboratories: Part I-Development

Brian A. Rappold , B.S.

Ann Lab Med 2022; 42: 121-140
The process of method development for a diagnostic assay based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) involves several disparate technologies and specialties. Additionally, method development details are typically not disclosed ...

Keywords: Tandem Mass Spectrometry, Liquid Chromatography, Method Development, Sample Preparation, Calibration, Internal Standards, Matrix Effects, Quality Control

Review Article l 01 March 2022

Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing

Saeam Shin, M.D., Ph.D. et al.

Ann Lab Med 2022; 42: 141-149
Standardization of cell-free DNA (cfDNA) testing processes is necessary to obtain clinically reliable results. The pre-analytical phase of cfDNA testing greatly influences the results because of the low proportion and stability of circulating tumor D...

Keywords: Cell-free nucleic acid, Circulating tumor DNA, Pre-analytical phase, Epidermal growth factor receptor, Clinical practice guidelines

Review Article l 01 January 2022

Hormone Immunoassay Interference: A 2021 Update

Khaldoun Ghazal, Pharm., Ph.D. et al.

Ann Lab Med 2022; 42: 3-23
Immunoassays are powerful qualitative and quantitative analytical techniques. Since the first description of an immunoassay method in 1959, advances have been made in assay designs and analytical characteristics, opening the door for their widespread...

Keywords: Immunoassay, Hormone, Interference, Heterophile antibodies, Biotin

Journal Information November, 2022
Vol.42 No.6
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